Scientific Publishing

• Artificial neural networks applied to quality-by-design: From formulation development to clinical outcome

  Marta F. Simões, Gabriel Silva, Ana C. Pinto, Marlene Fonseca, Nuno E. Silva, Rui M.A. Pinto, Sérgio Simões
  European Journal of Pharmaceutics and Biopharmaceutics, 2020, ISSN 0939-6411

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• Enhanced Solid-State Stability of Amorphous Ibrutinib Formulations Prepared by Hot-Melt Extrusion

  Marta F. Simões, Bernardo A. Nogueira, Andreia M. Tabanez, Rui Fausto, Rui M.A. Pinto, Sérgio Simões
  International Journal of Pharmaceutics, 2020, ISSN 0378-5173

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• Quality by design in pharmaceutical manufacturing: A systematic review of current status, challenges and future perspectives

  Helena Bigares Grangeia, Cláudia Silva, Sérgio Paulo Simões, Marco S. Reis
  European Journal of Pharmaceutics and Biopharmaceutics, Volume 147, Issue 9, Pages 19-37, 2020, ISSN 0939-6411

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• A 5-Stage Approach for a Systematic Screening and Development of Etravirine Amorphous Solid Dispersions by Hot-Melt Extrusion

  Simões MF, Pereira A, Cardoso S, Cadonau S, Werner K, Pinto RMA, Simões S.
  Molecular Pharmaceutics, 2019

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• Hot-melt extrusion in the pharmaceutical industry: toward filing a new drug application

  Marta F. Simões, Rui M. A.Pinto, Simões S.
  Drug Discovery Today, Volume 24, Issue 9, 2019, ISSN 1359-6446

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• Orphan drugs: major development challenges at the clinical stage

  Diogo A. Fonseca, Inês Amaral, Ana Catarina Pinto, Maria Dulce Cotrim
  Drug Discovery Today, 2019, ISSN 1359-6446

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• Critical process parameters of orodispersible films (ODFs)

  Branca M.A. Silva, Sílvia Vicente, Sofia Cunha, Cláudia Silva, Jorge F.J. Coelho, Sérgio Simões
  International Journal of Pharmaceutics, Volume 536, Issue 2, 2018, Page 507, ISSN 0378-5173

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• Intradermal Delivery of a Near-Infrared Photosensitizer Using Dissolving Microneedle Arrays

  Iman M.N. Hamdan, Ismaiel A. Tekko, Kyle B. Matchett, Luis G. Arnaut, Claudia S. Silva, Helen O. McCarthy, Ryan F. Donnelly
  Journal of Pharmaceutical Sciences, Volume 107, Issue 9, 2018, Pages 2439-2450, ISSN 0022-3549

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• Increasing the Bile Acid Sequestration Performance of Cationic Hydrogels by Using an Advanced/Controlled Polymerization Technique

  Mendonça, P.V., Matos, A., Sousa, A.F., Serra, A.C., Simões, S., Coelho, J.F.J.
  Pharm Res (2017), First Online: 16 June 2017, doi:10.1007/s11095-017-2204-5

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• Retrospective Quality by Design (rQbD) applied to the optimization of orodispersible films

  Branca M.A. Silva, Sílvia Vicente, Sofia Cunha, Jorge F.J. Coelho, Cláudia Silva, Marco Seabra Reis, Sérgio Simões
  International Journal of Pharmaceutics, Available online 17 June 2017, ISSN 0378-5173

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• A first in human study using photodynamic therapy with Redaporfin in advanced head and neck cancer

  Julio Oliveira, Eurico Monteiro, Juliana Santos, Jose Dinis Silva, Luis Almeida, Lúcio Lara Santos
  J Clin Oncol 35, 2017 (suppl; abstr e14056)

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• Ultrafast Dynamics of Manganese(III), Manganese(II), and Free-Base Bacteriochlorin: Is There Time for Photochemistry?

  Fabio A. Schaberle, Artur R. Abreu, Nuno P. F. Gonçalves, Gonçalo F. F. Sá, Mariette M. Pereira, and Luís G. Arnaut
  Inorg. Chem., 2017, 56 (5), pp 2677–2689.

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• The use of liposomes for the systemic delivery of RNAi therapeutics aiming at cancer treatment

  Lígia Catarina Gomes-da-Silva, Sérgio Simões, and João Nuno Moreira
  Liposomal Delivery Systems: Advances and Challenges. Panacea Biotec Ltd., India (Future Science Ltd) 2016. Pages 104-119

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• Outlining critical quality attributes (CQAs) as guidance for the development of orodispersible films

  A.F. Borges, C. Silva, J.F.J. Coelho, S. Simões
  Pharm. Dev. Technol. (2016) 1–9. doi:10.1080/10837450.2016.1199567

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• Hydrophobic polymers for orodispersible films: a quality by design approach

  Borges, A. F., Silva, B. M. A., Silva, C., Coelho, J.F.J., Simões, S., 2016
  Expert Opin. Drug Deliv. 13 (10): 1357-1374. doi: 10.1080/17425247.2016.1218458

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• Nucleolin overexpression in breast cancer cell sub-populations with different stem-like phenotype enables targeted intracellular delivery of synergistic drug combination

  Nuno A. Fonseca, Ana S. Rodrigues, Paulo Rodrigues-Santos, Vera Alves, Ana C. Gregório, Ângela Valério-Fernandes, Lígia C. Gomes-da-Silva, Manuel Santos Rosa, Vera Moura, João Ramalho-Santos, Sérgio Simões, João Nuno Moreira
  Biomaterials, Volume 69, November 2015, Pages 76-88, ISSN 0142-9612

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• Intravenous single-dose toxicity of redaporfin-based-photodynamic therapy in rodents

  Luis B. Rocha, Fábio Schaberle, Janusz M. Dąbrowski, Sérgio Simões, Luis G. Arnaut
  Int. J. Mol. Sci. 2015, 16(12), 29236-29249

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• Mucoadhesive oral films: The potential for unmet needs

  Silva, B.M.A., Borges, A.F., Silva, C., Coelho, J.F.J., Simões, S., 2015
  Int. J. Pharm. 494, 537–551. doi:10.1016/j.ijpharm.2015.08.038

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• Elimination of primary tumours and control of metastasis with rationally designed bacteriochlorin photodynamic therapy regimens

  Rocha LB, Gomes-da-Silva L, Dabrowski JM, Arnaut, LG.
  European Journal of Cancer. 2015; 51(13): 1822-30

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• Oral films: Current status and future perspectives II — Intellectual property, technologies and market needs, J. Control

  A.F. Borges, C. Silva, J.F.J. Coelho, S. Simões
  Release. 206 (2015) 108–121. doi:10.1016/j.jconrel.2015.03.012

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• Oral films: Current status and future perspectives

  A.F. Borges, C. Silva, J.F.J. Coelho, S. Simões
  J. Control. Release. 206 (2015) 1–19. doi:10.1016/j.jconrel.2015.03.006

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• Polymeric bile acid sequestrants—Synthesis using conventional methods and new approaches based on “controlled”/living radical polymerization

  Patrícia V. Mendonça, Arménio C. Serra, Cláudia L. Silva, Sérgio Simões, Jorge F.J. Coelho
  Progress in Polymer Science, Volume 38, Issues 3–4, March–April 2013, Pages 445-461, ISSN 0079-6700

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• Efficient intracellular delivery of siRNA with a safe multitargeted lipid-based nanoplatform

  Lígia C Gomes-da-Silva, Yolanda Fernández, Ibane Abasolo, Simo Schwartz Jr, José S Ramalho, Maria C Pedroso de Lima, Sérgio Simões, and João N Moreira
  Nanomedicine 2013 8:9, 1397-1413

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• Simultaneous active intracellular delivery of doxorubicin and C6-ceramide shifts the additive/antagonistic drug interaction of non-encapsulated combination

  Nuno A. Fonseca, Lígia C. Gomes-da-Silva, Vera Moura, Sérgio Simões, João Nuno Moreira
  Journal of Controlled Release, Volume 196, 28 December 2014, Pages 122-131, ISSN 0168-3659

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• Manufacturing and export provisions: Impact on the competitiveness of European pharmaceutical manufacturers and on the creation of jobs in Europe

  Vanda Vicente, Sérgio Simões
  Article first published online: October 9, 2014;Issue published: March 1, 2014

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• Photodynamic therapy efficacy enhanced by dynamics: the role of charge transfer and photostability in the selection of photosensitizers

  Arnaut LG, Pereira MM, Dąbrowski JM, Silva EF, Schaberle FA, Abreu AR, Rocha LB, Barsan MM, Urbańska K, Stochel G, Brett CM.
  Chemistry. 2014; 20(18):5346-57

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• Modulation of biodistribution, pharmacokinetics, and photosensitivity with the delivery vehicle of a bacteriochlorin photosensitizer for photodynamic therapy

  Saavedra, R., Rocha, L. B., Dąbrowski, J. M. and Arnaut, L. G.
  ChemMedChem, 2014, 9(2), 390-8.

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• Targeted and intracellular triggered delivery of therapeutics to cancer cells and the tumor microenvironment: impact on the treatment of breast cancer

  Moura, V.; Lacerda, M.; Figueiredo, P.; Corvo, M. L.; Cruz, M. E. M.; Soares, R.; Pedroso de Lima, M. C.; Simões, S.; Moreira, J. N.
  Breast Cancer Res Treat (2012) 133: 61. doi:10.1007/s10549-011-1688-7

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• Toward a siRNA-containing nanoparticle targeted to breast cancer cells and the tumor microenvironment

  Lígia C. Gomes-da-Silva, Adriana O. Santos, Luís M. Bimbo, Vera Moura, José S. Ramalho, Maria C. Pedroso de Lima, Sérgio Simões, João N. Moreira
  International Journal of Pharmaceutics, Volume 434, Issues 1–2, 15 September 2012, Pages 9-19, ISSN 0378-5173

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• Lipid-Based Nanoparticles for siRNA Delivery in Cancer Therapy: Paradigms and Challenges

  Lígia C. Gomes-da-Silva, Nuno A. Fonseca, Vera Moura, Maria C. Pedroso de Lima, Sérgio Simões, and João N. Moreira
  Accounts of Chemical Research 2012 45 (7), 1163-1171

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• Combined effects of singlet oxygen and hydroxyl radical in photodynamic therapy with photostable bacteriochlorins: evidence from intracellular fluorescence and increased photodynamic efficacy in vitro

  J.M. Dabrowski, L.G. Arnaut, M.M. Pereira, K. Urbanska, S. Simoes, G. Stochel, and L. Cortes
  Free radical biology & medicine, 2012, 52(7), 1188-2007

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• Development, Characterization and In Vitro Evaluation of Single or Co-Loaded Imatinib Mesylate Liposomal Formulations

  Pinto, Ana Catarina; Ângelo, Susana; Moreira, João Nuno; Simões, Sérgio
  Journal of Nanoscience and Nanotechnology, Volume 12, Number 3, March 2012, pp. 2891-2900(10)

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• Tissue uptake study and photodynamic therapy of melanoma-bearing mice with a nontoxic, effective chlorin

  Dąbrowski JM1, Krzykawska M, Arnaut LG, Pereira MM, Monteiro CJ, Simões S, Urbańska K, Stochel G.
  ChemMedChem. 2011 Sep 5;6(9):1715-26

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• Biodistribution and photodynamic efficacy of a water-soluble, stable, halogenated bacteriochlorin against melanoma

  Dąbrowski JM1, Urbanska K, Arnaut LG, Pereira MM, Abreu AR, Simões S, Stochel G
  ChemMedChem. 2011 Mar 7;6(3):465-75

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• Schedule treatment design and quantitative in vitro evaluation of chemotherapeutic combinations for metastatic prostate cancer therapy

  Pinto, A.C., Ângelo, S., Moreira, J.N. & Simões, S.
  Cancer Chemother Pharmacol (2011) 67: 275. doi:10.1007/s00280-010-1315-z

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• Targeting non-viral vectors to tumor cells and the tumor microenvironment

  Moura, V.; Lacerda, M.; Figueiredo, P.; Corvo, M. L.; Cruz, M. E. M.; Pedroso de Lima, M. C.; Simões, S.; Moreira, J. N.
  BMC Proc (2010) 4(Suppl 2): O26. doi:10.1186/1753-6561-4-S2-O26

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• Co-encapsulation of anti-BCR-ABL siRNA and imatinib mesylate in transferrin receptor-targeted sterically stabilized liposomes for chronic myeloid leukemia treatment

  Mendonça, L. S., Moreira, J. N., de Lima, M. C. P. and Simões, S.
  Biotechnol. Bioeng., 2010, 107: 884–893. doi:10.1002/bit.22858

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• Synthesis and photophysical characterization of a library of photostable halogenated bacteriochlorins: an access to near infrared chemistry

  Mariette M. Pereira, Carlos J.P. Monteiro, Ana V.C. Simões, Sara M.A. Pinto, Artur R. Abreu, Gonçalo F.F. Sá, Elsa F.F. Silva, Luis B. Rocha, Janusz M. Dabrowski, Sebastião J. Formosinho, Sérgio Simões, Luis G. Arnaut
  Tetrahedron. 2010; 669545-9551

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• New halogenated water-soluble chlorin and bacteriochlorin as photostable PDT sensitizers: synthesis, spectroscopy, photophysics, and in vitro photosensitizing efficacy

  Dabrowski JM, Arnaut LG, Pereira MM, Monteiro CJ, Urbańska K, Simões S, Stochel G.
  ChemMedChem. 2010 Oct 4;5(10):1770-80

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• Mechanisms of singlet-oxygen and superoxide-ion generation by porphyrins and bacteriochlorins and their implications in photodynamic therapy

  Silva EF, Serpa C, Dabrowski JM, Monteiro CJ, Formosinho SJ, Stochel G, Urbanska K, Simões S, Pereira MM, Arnaut LG.
  Chemistry. 2010 Aug 9;16(30):9273-86

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• Liposomal imatinib–mitoxantrone combination: Formulation development and therapeutic evaluation in an animal model of prostate cancer

  Pinto, A. C., Moreira, J. N. and Simões, S. (2011)
  Prostate, 71: 81–90. doi:10.1002/pros.21224

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• Ciprofloxacin sensitizes hormone-refractory prostate cancer cell lines to doxorubicin and docetaxel treatment on a schedule-dependent manner

  Pinto, A.C., Moreira, J.N. & Simões, S.
  Cancer Chemother Pharmacol (2009) 64: 445. doi:10.1007/s00280-008-0892-6

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• Synthesis and photophysical properties of amphiphilic halogenated bacteriochlorins: new opportunities for photodynamic therapy of cancer

  Mariette M. Pereira, Carlos J.P. Monteiro, Ana V.C. Simões, Sara M.A. Pinto, Luís G. Arnaut, Gonçalo F.F. Sá, Elsa F.F. Silva, Luís B. Rocha, Sérgio Simões and Sebastião J. Formosinho
  Journal of Porphyrins Phthalocyanines. 2009; 13: 567–573

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• Non-Viral Lipid-Based Nanoparticles for Targeted Cancer Systemic Gene Silencing

  Moreira, J. N.; Santos, A.; Moura, V.; Pedroso de Lima, M. C.; Simões, S.
  Journal of Nanoscience and Nanotechnology, Volume 8, Number 5, May 2008, pp. 2187-2204(18)

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• Synthesis of amphiphilic sulfonamide halogenated porphyrins: MALDI-TOFMS characterization and evaluation of 1-octanol/water partition coefficients

  C.J.P. Monteiro, M.M. Pereira, S.M.A. Pinto, A.V.C. Simões, G.F.F. Sá, L.G. Arnaut, S.J. Formosinho, S. Simões, and M.F. Wyatt
  Tetrahedron, 2008, 64(22), 5132-5138

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• Cationic liposomes for gene delivery

  Sérgio Simões, Ana Filipe, Henrique Faneca, Miguel Mano, Nuno Penacho, Nejat Düzgünes, and Maria Pedroso de Lima
  Expert Opinion On Drug Delivery, Vol. 2 , Iss. 2, 2005

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• Targeting of sterically stabilised pH-sensitive liposomes to human T-leukaemia cells

  Cristina Fonseca, João N. Moreira, Carlos J. Ciudad, Maria C. Pedroso de Lima, Sérgio Simões
  European Journal of Pharmaceutics and Biopharmaceutics, Volume 59, Issue 2, February 2005, Pages 359-366, ISSN 0939-6411

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• On the formulation of pH-sensitive liposomes with long circulation times

  Sérgio Simões, João Nuno Moreira, Cristina Fonseca, Nejat Düzgüneş, Maria C. Pedroso de Lima
  Advanced Drug Delivery Reviews, Volume 56, Issue 7, 23 April 2004, Pages 947-965, ISSN 0169-409X

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• Non-ligand polypeptide and liposome complexes as intracellular delivery vehicles

  Düzgünes, N.; Simões, S.; Slepushkin, V.; de Lima, M.C.P.
  Google Patents, 2001

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